INDIGO Biosciences Blog

[Free Resource] An Overview of Nuclear Receptors & Endocrine Disruption

June 7, 2019

From research available to us today, we know that there are many environmental chemicals that carry the potential to greatly impact the endocrine system. These are known as endocrine disrupting chemicals (EDCs), which are compounds that can alter drug and xenobiotic metabolic processes and interfere with the production, release, metabolism, and elimination of naturally occurring hormones.

Through a close examination of suspected endocrine and metabolic disruptors and examples of EDC interaction, we can better understand the ability that these compounds have to impact various nuclear receptors and pathways and elicit both agonist- and antagonist-like effects.

INDIGO Biosciences offers insights on nuclear receptors and endocrine and metabolic disruption for those seeking more information in their field of study.

What Are Endocrine Disruptors?

Endocrine disruptors are specific chemicals that disrupt or interfere with elements of the endocrine system. This critical system contains the glands that generate essential hormones for controlling metabolism, growth, tissue, reproduction, mood, and other factors and functions in the human body. The most important glands in humans are the thyroid and adrenal glands—central locations that regulate life-changing hormones, which stimulate cells and tissues and affect their activity.

How Do Endocrine Disruptors Affect Humans?

Endocrine disruptors can mimic the existing hormones humans have in our bodies, causing the intensity or function of these hormones to change. Depending on the type and outcome, EDs can impact puberty, immune function, stress, weight, bone health, and more. What many in the industry call the “dirty dozen” endocrine disruptors are chemicals most people are familiar with, including BPA, dioxin, and DDT. Some of these hormone disruptors can be found in foods such as meat, dairy, and fish, which often means the food is contaminated. Endocrine disruptors found in water include pesticides, perchlorate, and BPA, and the phthalates found in many cosmetics are EDs as well.

Free Resource

Studying the activity and impact of endocrine disruptors is a vital field in scientific exploration today. The more we examine these chemicals, the more we can pinpoint solutions for preventing and remedying negative health conditions. Are you interested in learning more? A free whitepaper from INDIGO Biosciences offers information on endocrine disruption, metabolic disruption, mechanistic approaches, and more. Download this informative resource today to enhance your own research.

In it, you’ll find information on:

  • Important EDCs and their mechanism of action, including their interaction with NRs
  • The potential for EDCs to disturb hormonal regulation and the normal endocrine system
  • The impact of endocrine disruptors on human and animal health and reproduction
  • The main suspected endocrine and metabolic disruptors and mechanistic approaches

Do you have deeper questions about this subject? Request information from the team at INDIGO Biosciences to learn more, explore related testing, and request custom research studies.

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INDIGO Biosciences - The right partner for all your discovery and toxicology needs.

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