Through further examination of enzyme induction and its relationship to drug-drug interaction, we can better understand the effects of certain drugs and develop safer solutions for diseases and conditions.
INDIGO Biosciences offers insights on enzyme induction, drug-drug interaction, and gene expression for those seeking more information to supplement their research.
What is Enzyme Induction?
Enzyme induction is the enhancement of an enzyme’s expression, done by a specific molecule. Enzyme inhibition is the opposite function of enzyme induction, inhibiting the expression or manufacture of an enzyme. In researching and developing drugs, enzyme induction may indicate a less effective drug and may also impact the toxicity or negative effects that a drug can have on the body. When exposed to certain drugs, these enzymes can become expressed and enhanced.
In addition to affecting the metabolism of endogenous compounds, enzyme induction affects various aspects of drug-drug interaction and toxicity. In the case of drugs with active metabolites to impact metabolism, enzyme induction can lead to increased drug effects and possible toxicity. Drug-drug interaction that can occur include a reduction in the concentration of multiple drugs that are metabolized by a single enzyme.
Understanding the impact of enzyme induction on drug interactions can help set improved recommendations for clinical monitoring, medication adjustments relative to specific dosages, and co-prescribing.
Studying enzyme induction can help inform drug-drug interactions and toxicity and further the research of today’s drug developers. Are you interested in learning more? A free whitepaper from INDIGO Biosciences offers information on nuclear hormone receptors, gene expression, and more. Download this resource today for detailed insights and an informative overview of gene expression.
Find information on:
- Nuclear receptor functional domains and structure
- The mechanism of gene regulation by nuclear receptors
- Transcriptional proteins and aryl hydrocarbon receptors
- The four classifications of gene expression activity
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